Wednesday, January 23, 2013

Va. university lockdown ends; gun report a hoax

(AP) ? A lockdown at a Virginia university has been lifted after state police determined a report of a gunman on campus to be a hoax.

Virginia State Police Public Relations Director Corinne N. Geller said in a news release Wednesday night that police officers from various departments who flooded the campus following the initial report were leaving and the lockdown was being lifted.

Geller said that the UVA-Wise student called 911 shortly before 9 p.m. to report that he had seen an armed gunman on campus. She said police officers from the university, town, county and state immediately responded and began a building-by-building search while state police agents interviewed the student.

Geller said during that interview, "the student confessed that it was a hoax."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-01-23-UVA-Lockdown/id-2324723b9b8147ae9df56f295c519454

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Here's a Simple Card Trick You Can Learn in a Minute

Our friends at BoingBoing put together a video to show you a simple and fun card trick that anyone can learn in no time: Using a deck of playing cards, make three piles of three cards each. Flip a pile over to note the bottom card and then combine all three piles into one, making sure that the pile you flipped over is on top. After that, spell out the card you saw. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/xQ1Oa88C-DM/heres-a-simple-card-trick-you-can-learn-in-a-minute

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BPA substitute could spell trouble: Experiments show bisphenol S also disrupts hormone activity

Jan. 22, 2013 ? A few years ago, manufacturers of water bottles, food containers, and baby products had a big problem. A key ingredient of the plastics they used to make their merchandise, an organic compound called bisphenol A, had been linked by scientists to diabetes, asthma and cancer and altered prostate and neurological development. The FDA and state legislatures were considering action to restrict BPA's use, and the public was pressuring retailers to remove BPA-containing items from their shelves.

The industry responded by creating "BPA-free" products, which were made from plastic containing a compound called bisphenol S. In addition to having similar names, BPA and BPS share a similar structure and versatility: BPS is now known to be used in everything from currency to thermal receipt paper, and widespread human exposure to BPS was confirmed in a 2012 analysis of urine samples taken in the U.S., Japan, China and five other Asian countries.

According to a study by University of Texas Medical Branch at Galveston researchers, though, BPS also resembles BPA in a more problematic way. Like BPA, the study found, BPS disrupts cellular responses to the hormone estrogen, changing patterns of cell growth and death and hormone release. Also like BPA, it does so at extremely low levels of exposure.

"Our studies show that BPS is active at femtomolar to picomolar concentrations just like endogenous hormones -- that's in the range of parts per trillion to quadrillion," said UTMB professor Cheryl Watson, senior author of a paper on the study now online in the advance publications section of Environmental Health Perspectives. "Those are levels likely to be produced by BPS leaching from containers into their contents."

Watson and graduate student Ren? Vi?as conducted cell-culture experiments to examine the effects of BPS on a form of signaling that involves estrogen receptors -- the "receivers" of a biochemical message -- acting in the cell's outer membrane instead of the cell nucleus. Where nuclear signaling involves interaction with DNA to produce proteins and requires hours to days, membrane signaling (also called "non-genomic" signaling) acts through much quicker mechanisms, generating a response in seconds or minutes.

Watson and Vi?as focused on key biochemical pathways that are normally stimulated when estrogen activates membrane receptors. One, involving a protein known as ERK, is linked to cell growth; another, labeled JNK, is tied to cell death. In addition, they examined the ability of BPS to activate proteins called caspases (also linked to cell death) and promote the release of prolactin, a hormone that stimulates lactation and influences many other functions.

"These pathways form a complicated web of signals, and we're going to need to study them more closely to fully understand how they work," Watson said. "On its own, though, this study shows us that very low levels of BPS can disrupt natural estrogen hormone actions in ways similar to what we see with BPA. That's a real cause for concern."

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The above story is reprinted from materials provided by University of Texas Medical Branch at Galveston, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Ren? Vi?as, Cheryl S. Watson. Bisphenol S Disrupts Estradiol-Induced Nongenomic Signaling in a Rat Pituitary Cell Line: Effects on Cell Functions. Environmental Health Perspectives, 2013; DOI: 10.1289/ehp.1205826

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/y6NAhE6ZclY/130122191412.htm

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Enzyme helps cancer cells avoid genetic instability

Tuesday, January 22, 2013

Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in the January 21st issue of The Journal of Cell Biology.

The BRCA1 protein helps to mend double-strand DNA breaks by promoting homologous recombination. Without it, cells can amass broken, jumbled, and fused chromosomes, which may cause them to stop growing or die. Although cells lacking BRCA1 seem like they should be vulnerable, loss of the protein instead seems to boost abnormal growth.

Recent studies have shown that cells lacking BRCA1 compensate by cutting back on 53BP1. This protein helps orchestrate a different DNA repair mechanism, nonhomologous end joining (NHEJ), and it thwarts a key step in homologous recombination. Researchers think that, in cells without BRCA1, 53BP1 spurs excessive NHEJ that can cause fatal chromosomal chaos. But with 53BP1 out of the way, the cells are able to resume homologous recombination. That might explain why cells that lack BRCA1 and eliminate 53BP1 can withstand traditional chemotherapy compounds and PARP inhibitors, a new generation of anti-cancer drugs that are in clinical trials. But how do cancer cells turn down 53BP1?

Researchers previously found that certain mutant fibroblasts increase production of cathepsin L, a protease that destroys 53BP1. BRCA1-deficient cancer cells take advantage of the same mechanism, according to a team of researchers led by Susana Gonzalo from the Washington University School of Medicine. When they cultured breast cancer cells that were missing BRCA1, the cells stopped growing. After two weeks of lethargy, however, some cells, which the researchers dubbed BOGA cells (BRCA1-deficient cells that overcome growth arrest), began to divide again. These cells showed increased levels of cathepsin L and reduced amounts of 53BP1. Eliminating cathepsin L from BOGA cells or dosing them with vitamin D, a cathepsin L inhibitor, prevented the decline in 53BP1 abundance.

To find out whether boosting cathepsin L levels enabled the cancer cells to restart homologous recombination, the researchers monitored sites of DNA damage tagged by RAD51, a protein that helps promote homologous recombination. The cells that had stopped growing did not display RAD51 foci, but these foci were prevalent in BOGA cells with reduced 53BP1. Removing cathepsin L from BOGA cells increased 53BP1 levels and diminished the number of RAD51 foci.

If cells can't perform homologous recombination, they turn to repair mechanisms such as NHEJ that can lead to jumbled chromosomes. However, after DNA-breaking doses of radiation, BOGA cells exhibited few chromosome defects. The number of these flaws climbed after the researchers stabilized 53BP1 levels by inhibiting cathepsin L or trimming its abundance.

The team then analyzed tumor samples from breast cancer patients. Researchers suspect that cathepsin L attacks 53BP1 by entering the nucleus. Samples from patients with BRCA1 mutations or with triple-negative breast cancer?an aggressive form of the disease?showed high levels of nuclear cathepsin L and reduced quantities of 53BP1. That suggests tumors in these patients hike the amounts of cathepsin L in the nucleus to break down 53BP1 and restore homologous recombination.

"It's a new pathway that explains how breast cancer cells lose 53BP1," says Gonzalo. How cancer cells boost nuclear cathepsin L levels is unclear, she notes.

Triple-negative breast cancers are currently identified by their lack of Her2 and the estrogen and progesterone receptors. The work suggests that another trio of measurements?the amounts of 53BP1, cathepsin L, and vitamin D receptor in the nucleus?might help identify patients that are resistant to current breast cancer treatments. These people might respond to cathepsin inhibitors, some of which are undergoing animal testing. These compounds might steer the cells away from homologous recombination and leave them vulnerable to other therapies.

###

Grotsky, D.A., et al. 2013. J. Cell Biol. doi:10.1083/jcb.201204053.

Rockefeller University Press: http://www.rupress.org/

Thanks to Rockefeller University Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126382/Enzyme_helps_cancer_cells_avoid_genetic_instability

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Tuesday, January 22, 2013

Flour Sack Mama: Product Review: ReBody Hunger Chews

In a perfect world I would tell you that I reviewed a new product that helped me lose lots of weight. That didn't exactly happen.

I signed up to review some products, including ReBody Hunger Chews, and I agreed to write a little about them here.?

The good news is, this happened around the first of the year when I was recommitting, like millions of other people, to more regular exercising and cleaning up my diet. ?While I put less attention on my own health around the busy holiday times, I had gained a few pounds. ?Then, I started getting back to my pre-holiday size around the time I was taking these hunger chews. Was there a cause and effect? ?I don't really know.

The ReBody Hunger Chews are made from Satiereal Saffron Extract and are supposed to help curb cravings. ?They taste great in mandarin orange and use natural flavoring. ?Their relatively short ingredient list offers me some peace of mind, and I especially like that they don't contain artificial sweeteners. ?Thanks to Naturally Savvy for the chance to try them.

*I received a free sample of ReBody chews and my opinions are my own.

Source: http://floursackmama.blogspot.com/2013/01/product-review-rebody-hunger-chews.html

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Green Blog: Taking a Harder Look at Fracking and Health

PHILADELPHIA ? A coalition of academic researchers in the United States is preparing to shine a rigorous scientific light on the polarized and often emotional debate over whether fracking for natural gas is hazardous to human health.

Some five years after the controversial combination of hydraulic fracturing and horizontal drilling in the gas-rich Marcellus Shale in Pennsylvania and surrounding states got under way, a team of toxicologists from the University of Pennsylvania is leading a national effort to study the health effects of fracking.

The university?s Center for Excellence in Environmental Toxicology has organized a working group with researchers at other top universities including Columbia, Johns Hopkins and the University of North Carolina to investigate and analyze reports of nausea, headaches, breathing difficulties and other ills from people who live near gas drilling sites, compressor stations or waste-water pits.


The aim is to bring academic discipline to the unresolved national debate, which pits an industry that denies any link between fracking and environmental contamination against those who assert that fracking poisons air and water with natural and man-made chemicals that can cause cancer, birth defects and other illnesses.

?There is an enormous amount of rhetoric on both sides,? said Trevor Penning, head of the Penn toxicology center and the driving force behind the Environmental Health Sciences Core Center Hydrofracking Working Group. ?We felt that because we are situated in Pennsylvania, we had a duty to get on top of what was known and what was not known.?

Dr. Penning has asked 17 centers affiliated with the National Institute for Environmental Health Sciences to take part in different aspects of research into the health effects of fracking. Ten have so far accepted, he said in an interview.

Among the questions to be answered, Dr. Penning said, is the toxicity of the ?flowback? water that emerges from gas wells after they are fracked, which contains a mix of man-made and naturally occurring chemicals. Fracking forces a mixture of water, sand and chemicals at high pressure a mile or more underground to facture the shale and release the natural gas ? mainly methane ?inside it.

Determining whether flowback water or fracking fluid is dangerous to health is challenging if the chemicals and their combinations are not fully disclosed, he said. The teams will also look at whether air quality is dangerously affected by the flaring of waste gases, and whether the industry?s extensive use of diesel fuel for trucks, drills and compressor stations is polluting the air to unhealthy levels near gas installations.

?We don?t know if the levels we are dealing with are hazardous,? he said. ?We think it?s unsafe, but we don?t know it?s unsafe.?

The first project, based on work at Penn, surveyed residents in the Marcellus Shale regions of Pennsylvania about their health symptoms and whether they believed their symptoms were related to local gas drilling. Results are expected to be published in mid-February.

Future projects, which depend on obtaining financing from the National Institute for Environmental Health Sciences, would include working with a cancer center at the University of Texas to compare the heavily drilled Barnett Shale in that state with the Marcellus and to see whether state laws on gas drilling have taken public health into consideration.

Also awaiting funds is a plan to use a Harvard University mapping tool to correlate gas installations with reports of sickness and a proposal to study the health outcomes of targeted populations by examining billing data from insurance companies.

Dr. Penning said the planned research projects won?t duplicate the ongoing work of the federal Environmental Protection Agency, which is conducting its own research into whether fracking contaminates water supplies. That study is not explicitly focused on the health effects of any contamination, he said.

Asked why academics are only now proposing a systematic study of fracking?s health effects some five years after the shale boom began in earnest in Pennsylvania, Dr. Penning replied, ?Politics.?

With a strongly pro-industry administration led by Pennsylvania?s Republican governor, Tom Corbett, and a Republican-controlled legislature that has recently approved an industry-friendly gas-drilling law, state funding has not been available for research into whether the industry?s activities have negative health effects, Dr. Penning said.

?Academia can only do work if there?s funding to do that work,? he said.

The projects may guide industry and government worldwide in developing shale gas reserves, whch are expected to become a major global energy source.

?The Marcellus Shale is a microcosm of what?s going on across the globe,? Dr. Penning said.

Source: http://green.blogs.nytimes.com/2013/01/21/taking-a-harder-look-at-fracking-and-health/?partner=rss&emc=rss

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